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Alpha2EQ
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Equine orthobiologic for veterinarians

The horse’s own anti-inflammatory molecule,
put to work.

The only orthobiologic shown to deliver functionally isolated, active α2M to sites of inflammation, resulting in clinical benefits.

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Derived from the horse

α2M from the horse’s own blood, functionally isolated with one stall-side draw. Nothing foreign, nothing synthetic.

Tetrameric and fully functional

AlphaActive™ filtration delivers the tetrameric form of α2M, the only form that is fully functional.

Not a corticosteroid

A drug-free, non-corticosteroid anti-inflammatory that works without immunosuppression.

Multi-dose, freezable

One blood draw yields multiple doses that can be frozen for up to 12 months.

Recommend a product you can
explain, verify, and defend.

Orthobiologic “more is better” claims haven’t held up to independent scrutiny. Alpha2EQ® is built on a mechanism: one molecule, functionally isolated, delivered where inflammation is.

Diagram of the alpha-2-macroglobulin tetramer trapping a protease at its bait region
α2M: four identical subunits arranged as a tetramer, a “dimer of dimers”. Only this form is fully functional.

  • What is α2M?

    Alpha-2-macroglobulin is a glycoprotein in the horse’s blood. By binding pro-inflammatory cytokines and trapping and removing proteases, it acts as a naturally occurring anti-inflammatory molecule.

  • Why isolation matters

    AlphaActive™ filtration functionally isolates α2M from the horse’s own plasma, creating an acellular product focused on α2M: the only orthobiologic shown to contain functional α2M.

  • Why acellular matters

    Acellular means none of the concerns about the potential negative effects seen with many orthobiologics that contain cells. Acellular also means no activated white blood cells known to break down and inactivate α2M.

Mechanism of action

Traps. Binds.
Removes.

  1. Traps proteases

    When a protease, including the MMP and ADAMTS proteases, cleaves α2M’s bait region, a conformational change is triggered that traps and binds the protease, blocking it from reaching its substrate.

  2. Binds pro-inflammatory cytokines

    Protease entrapping α2M binds pro-inflammatory cytokines, including IL-1β and TNFα, the principal mediators of inflammation, without immunosuppression or the other known deleterious effects of corticosteroids.

  3. Removes them from the site

    Trapping exposes the receptor binding sites on α2M so that only protease entrapping α2M is recognized, bound and cleared via phagocytosis. α2M that has not trapped a protease is not cleared, and remains functional at the site of inflammation.

Only the tetrameric “dimer of dimers” is fully functional. Alpha2EQ® has been shown to deliver α2M in this form.

Demonstrated benefits in the
management of osteoarthritis.

In vitro and in vivo

Multiple studies, both in vitro and in vivo, have demonstrated the mechanisms of how, and the benefits that result from, the use of supplemental α2M in osteoarthritic and post-traumatic osteoarthritic joints.

  • Non-specific inhibition of all four classes of proteases, including the collagenases and aggrecanases that degrade cartilage
  • Binding and clearance of IL-1β and TNFα, the principal pro-inflammatory cytokines in joint disease
  • In multiple models of OA and PTOA, supplemental α2M has been shown to induce upregulation of anabolic genes and downregulation of catabolic genes in both chondrocytes and synoviocytes

The first to bring alpha-2-macroglobulin to the veterinary space, and continuing to lead innovative clinical applications and research on α2M.

“The neck has never felt as good as it has felt with Alpha2EQ. Even better than cortisone and shockwave therapy.”

Dr. Beau Whitaker
Brazos Valley Equine Hospitals

Go deeper

Integrates cleanly into
the toolkit you already have.

Alpha2EQ® has no contraindications for use before or after other therapies, and processes stall-side, so it fits how you already manage joints, soft tissues, and airways.

Compatible with

  • PRP
  • IRAP
  • Stem cells
  • Amnion-based products
  • Shockwave therapy

Freedom to use on any horse

Alpha2EQ® is drug-free, not a corticosteroid, and native to the horse, so it can be used in horses actively competing in regulated competitions, and in horses where corticosteroids should be avoided: pregnant mares, horses with Cushing’s (PPID), insulin-dysregulated (ID) horses, and horses previously clinically affected with EPM.

Easy, stall-side processing

  1. Draw blood into the provided ACD-A syringes
  2. Spin to separate plasma
  3. Spin plasma through AlphaActive™ filtration to functionally isolate α2M
  4. Draw doses; administer to joints, soft tissues, or airways
  5. Freeze remaining doses for up to 12 months

Full processing protocols

Alpha2EQ®-15 and Alpha2EQ®-30 kits
  • Alpha2EQ®-15 Smaller-yield kit for single-site treatment.
  • Alpha2EQ®-30 Higher-yield kit for multi-site, multi-dose visits.
Request information

Talk with the Alpha2EQ® clinical team

Tell us a little about your practice and what you want to know. A member of the clinical team will follow up within one business day.

  • No obligation, no sales pressure. Clinical questions welcome
  • Protocol training, dosing guidance and kit logistics
  • Mechanism-of-action data, white papers, and references on request

Prefer to call? 800-287-8156

Cases you’re managing, current orthobiologics in use, questions about protocol.

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